PEPFAR has supported the USAID-funded Leadership, Management, and Governance Project, the USAID-funded AIDSTAR-Two Project, the Human Sciences Research Council (HSRC), and partnered with leading child development experts to undertake a three-phase research activity to ensure an effective and comprehensive response to the HIV epidemic in children. The first phase involved a literature review of evidence on the impact of HIV and AIDS on children, and the associated risks to physical and psychological health, and to social outcomes. To further understand the potential long-term implications of these adverse outcomes, the second phase complemented these findings with a review of the broader body of child development research. This phase also identified evidence-based strategies that protect children from harm and mitigate harm where it occurs. The third phase expanded on the first two by designing a research model that integrates these findings and uses the data to estimate impacts at the population level; these data can then inform priorities for policy and programming for children affected by HIV and AIDS. OVCsupport hosted HSRC’s Dr. Chris Desmond for a webinar on the findings of the three phases of research.